• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Home
  • About
  • Book
  • Amazon
  • Cabo Rental
  • Projects…
    • The Inuit were never in Ketosis
    • The Manifesto
    • Gut Health
    • Elixa Probiotic
    • Resistant Starch
  • Archive

Free The Animal

Ex Navy Officer. Owner of Businesses. Digital Entrepreneur. Expat Living in Thailand. 5,000 Biting Blog Post on Everything since 2003.

I Told You
Megan McArdle

Counterintuitive Cancer Therapy

April 14, 2008 5 Comments

Get a load of this.

Fasting for two days protects healthy cells against chemotherapy, according to a study appearing online the week of Mar. 31 in PNAS Early Edition. Mice given a high dose of chemotherapy after fasting continued to thrive. The same dose killed half the normally fed mice and caused lasting weight and energy loss in the survivors.

…

The idea for the study came from the Longo group’s previous research on aging in cellular systems, primarily lowly baker’s yeast.

About five years ago, Longo was thinking about the genetic pathways involved both in the starvation response and in mammalian tumors.

When the pathways are silenced, starved cells go into what Longo calls a maintenance mode characterized by extreme resistance to stresses. In essence the cells are waiting out the lean period, much like hibernating animals.

But tumors by definition disobey orders to stop growing because the same genetic pathways are stuck in an “on” mode.

That could mean, Longo realized, that the starvation response might differentiate normal and cancer cells by their stress resistance, and that healthy cells might withstand much more chemotherapy than cancer cells.

The shield for healthy cells does not need to be perfect, Longo said. What matters is the difference in stress resistance between healthy and cancerous cells.

During the study, conducted both at USC and in the laboratory of Lizzia Raffaghello at Gaslini Children’s Hospital in Genoa, Italy, the researchers found that current chemotherapy drugs kill as many healthy mammalian cells as cancer cells.

“(But) we reached a two to five-fold difference between normal and cancer cells, including human cells in culture. More importantly, we consistently showed that mice were highly protected while cancer cells remained sensitive,” Longo said.

If healthy human cells were just twice as resistant as cancer cells, oncologists could increase the dose or frequency of chemotherapy.

“We were able to reach a 1,000-fold differential resistance using a tumor model in baker’s yeast. If we get to just a 10-20 fold differential toxicity with human metastatic cancers, all of a sudden it’s a completely different game against cancer,” Longo said.

I find this very interesting, particularly in light of an already well known benefit of fasting: autophagy. Here’s the short version.

(link: Art)

Share44
Tweet10
Pin
54 Shares

Filed Under: General Tagged With: fasting, cancer

PATREON SUPPORT

My own on-the-scene expat photos, stories, podcasts, and video adventures, currently from exotic Thailand. Plus, anything else I write or video about.

Become a Patron

VACATION IN MY CABO CONDO

THE FAT LOSS BLUEPRINT


Elixa Probiotic is a British biotech manufacturer in Oxford, UK. U.S. Demand is now so high they've established distribution centers in Illinois, Nevada, and New Jersey.

Still, sell-outs happen regularly, so order now to avoid a waiting list.

Reader Interactions

Comments

  1. Kyle Bennett April 15, 2008 at 08:37

    Thanks for passing this on, Rich. The guy in the office next to mine just got diagnosed with lymphoma and came to work bald after his first round of chemo (prognosis very good). I sent this to him and he's going to look into it.

    Reply
  2. Richard Nikoley April 15, 2008 at 10:10

    Kyle:

    Check back later today because I have a whole bunch of links about cancer therapy. It'll be in a new post.

    Reply
  3. Richard Nikoley April 15, 2008 at 10:20

    …I just emailed you the link train because I don't know when today I'll get to the post.

    Reply
  4. Ken August 16, 2009 at 19:46

    Richard,

    I would very much like to see the information you think relevant to cancer; specifically, prostate cancer.

    Reply
  5. Richard Nikoley August 17, 2009 at 09:31

    I don’t think I’ve touched on prostate cancer specifically, but I have done a lot with the general connection to vitamin D deficiency.

    Search the blog for both cancer and vitamin D, and that will get you the posts.

    Reply

Leave a Reply to Richard Nikoley Cancel reply

Your email address will not be published. Required fields are marked *

Primary Sidebar

Search FreeTheAnimal

Social Follow

Facebook3k
Facebook
fb-share-icon
Twitter6k
Visit Us
Follow Me
Tweet
Instagram358
Pinterest118k
Pinterest
fb-share-icon
YouTube798
YouTube
Follow by Email8k
RSS780

Post Notification Options

About FreeTheAnimal

I'm Richard Nikoley. Free The Animal began in 2003 and as of 2020, has 5,000 posts and 120,000 comments from readers. I blog what I wish...from lifestyle to philosophy, politics, social antagonism, adventure travel, nomad living, location and time independent—"while you sleep"— income, and food. I intended to travel the world "homeless" but the Covid-19 panic-demic squashed that. I've become an American expat living in rural Thailand where I've built a home. I celebrate the audacity and hubris to live by your own exclusive authority and take your own chances. [Read more...]

CLICK HERE to shop Amazon. Costs you nothing.

Shop Amazon

My own on-the-scene expat photos, stories, podcasts, and video adventures, currently from exotic Thailand

Become a Patron

Gastrointestinal Health

Elixa Probiotic is a British biotech manufacturer in Oxford, UK. U.S. Demand is now so high they've established distribution centers in Illinois, Nevada, and New Jersey.

Still, sell-outs happen regularly, so order now to avoid a waiting list.

Elixa Probiotic

My Book

Free The Animal Book

Recent Posts

Covid-19: You’re Not Entitled to Your Own All-Cause Mortality

In the never-ending diet and health antagonism, it happens that researchers, clinicians, and various advocates trend toward "specialization" in a ...

Read More

My Thoughts About The 2020 Fraudulent Election

Since a picture is worth a thousand words, let's call it 500 words of thoughts about the election circus spectacle and 500 words about considering ...

Read More

A COVID Cult and Clown Car Roundup

Political correctness is communist propaganda writ small. In my study of communist societies, I came to the conclusion that the purpose of communist ...

Read More

You Can’t Recount Your Way Out of This

It's a hot mess inside of a shitstorm From about 1990 until midterms, 2018, I was a non-voter, even though I generally supported libertarian and ...

Read More

November 3rd

Less than a week out and looking forward to forgetting about it for another 4 years. 320+, and the popular vote. Bank on it. That is all. ...

Read More

Popular Posts

Coronavirus #3: Denise Minger is Thorough But Misses the Boats92 Total Shares
My 8 Weeks in Thailand #188 Total Shares
Covid-19 Is Impeachment 3.0; BLM Riots, 4.0; Re-Lockdown, 5.083 Total Shares
My Musings on the Coronavirus (Covid-19)73 Total Shares
Have You Forgotten? Richard Lothar Nikoley Doesn’t Give An Eff What You “Think”64 Total Shares
Coronavirus #2: The Dumb and the Dumber58 Total Shares
I Met A Dry Fasting Nut39 Total Shares
CovidScam Unravels. Backlash Grows and Intensifies.35 Total Shares
Coronavirus #1: The Innocent and the Guilty30 Total Shares
Everything I Thought I Lost28 Total Shares

Last 10 Comments

  • Richard Nikoley on Covid-19: You’re Not Entitled to Your Own All-Cause Mortality
  • Richard Nikoley on Covid-19: You’re Not Entitled to Your Own All-Cause Mortality
  • PaleRider1980 on Covid-19: You’re Not Entitled to Your Own All-Cause Mortality
  • Richard Nikoley on My Thoughts About The 2020 Fraudulent Election
  • Richard Nikoley on My Thoughts About The 2020 Fraudulent Election
  • EatLessMoveMoore on My Thoughts About The 2020 Fraudulent Election
  • Big on My Thoughts About The 2020 Fraudulent Election
  • Richard Nikoley on You Can’t Recount Your Way Out of This
  • Anonymous on You Can’t Recount Your Way Out of This
  • Chung Ho-Lee on A COVID Cult and Clown Car Roundup

© 2021 All Rights Reserved · Free The Animal Return to top