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Friday Links: Art Ayers Keeps Cooling Inflammation; New Potential Type 2 Diabetes Drug; Case Study

~ Dr. Art Ayers contacted me yesterday for comments prior to his latest post and really, the only meaningful thing I had was to make sure Tim and Dr. BG were in for lots of credit.

Paleo Gut Flora Repair

I was shocked to learn that there were some paleo (meat and veggie) eaters who were getting cured with resistant starch. I didn’t know that some were sick and, as I said in a previous post, I would not have guessed that starch was good for anything, but spikes in blood sugar. I was rudely awakened by the shouts of Richard Nikoley on Free the Animal, though I suspect the sanity behind the argument came from Tim and Dr. BG (She is always right.) He presented a kind of Second Coming of Paleo with resistant starch to feed the gut flora as soluble fiber. How could I question food for flora? (How could I question Nikoley without my karate gi?) […]

paleo Diet without Soluble Fiber is Hard on Gut Flora
People get sick on paleo, because they don’t feed their flora. Gut flora are needed to supply vitamins, short chain fatty acids and immune system stimulants. If you don’t feed your flora you get vitamin deficiencies, gut inflammation and autoimmune diseases (Treg deficiency). It is very important to remember that feeding your flora means matching the soluble fiber with the existing flora. Most people make the mistake of assuming that if they change their diet, then their flora will also change. Their flora will adapt with each of their hundred different species of gut bacteria increasing or decreasing in numbers, but no new genes will be present to digest new soluble fiber. Eating a meat diet will eventually eliminate gut bacteria needed to digest some plant materials and produce intolerances. The missing bacteria will not be regained upon return to eating plants again. [emphasis added]

Use it or lose it. Art goes on to talk a lot about the need for probiotics, and not all that stuff in yogurt, kefir, or any other lacto-strains. Rather, you need the bacteria from dirt. Ironically, it appears some of the primary keys to healing broken guts are to be found in shit pills, dirt, and even baby-poop sausages. Then you feed them well (e.g., resistant starch) to keep them established. Go read it. Perhaps—coming from a PhD in Molecular, Cellular, and Developmental Biology who has professored all over the world—some of the ignorant pip-squeaks and clowns I see in comments mostly elsewhere will get a clue, since it’s not coming from me. Yes, I’m lafing at you, and you know who you are. Keep on reading, though, even the comments I post. All y’all seem to know every last detail about me.

Tim and I owe Dr. BG AnimalPharm (link removed) (Grace) on this. Art’s post is essentially what Grace has been telling us. She blew her stack at us for some of what we said in that Latest in Paleo podcast, where we downplayed probiotics in place of feeding the gut. So, we ended up making peace by making her science editor of the book and I also went and got three soil-based probiotic products to try for myself. I’m a solid 2+ weeks into those. I’ve taken the store-bought lacto stuff, chowed yogurt, made my own kefir, but have never noticed anything particular.

That has now changed. I’ll post about it next week, along with the products I’m using. In impressed, to say the least. So yea, perhaps the reason RS doesn’t work for some, or in some cases seems to exacerbate some conditions, is that it can’t feed what doesn’t exist.

~ Successful Clinical Trial of Type 2 Drug That Works on Intestinal Organisms

DiabetesHealth

BROOMFIELD, Colo.–microbiome TherapeuticsTM has announced positive results from its clinical trial of a microbiome modulator, NM504, in development for type 2 diabetes and pre-diabetes.

NM504 is designed to improve glucose tolerance and other metabolic parameters in patients with diabetes by shifting the gastrointestinal microbiome–the micro-organisms that inhabit the human body.

Studies have shown that people with type 2 diabetics typically have gastrointestinal dysbiosis, or microbial imbalances, that may contribute to the metabolic dysfunction associated with the condition.

The double-blind, randomized, placebo-controlled trial assessed whether NM504 administered for four weeks could improve the glucose tolerance of subjects with pre-diabetes and untreated type 2 diabetes by modulating the gastrointestinal microbiome. The study enrolled 42 subjects.

Top-line results show that twice-daily oral administration of NM504 reduced postprandial serum glucose levels and increased insulin sensitivity in these subjects. The results were statistically significant as measured by an oral glucose tolerance test. NM504 also decreased markers of chronic inflammation and blood lipids in treated subjects, and it decreased appetite as determined by a validated physician-administered scale. NM504 was well tolerated and patient compliance was excellent.

“”This trial represents a milestone both for MBT and the emerging field of microbiome therapy,” noted Steve Orndorff, CEO of microbiome Therapeutics. “”NM504 is the first therapeutic shown to directly modulate the GI microbiome in diabetics, and this study is among the first randomized, placebo-controlled trials of a microbiome-based therapy to achieve a statistically significant medical outcome. We look forward to reporting more detailed data on this study at upcoming scientific meetings.”

Whether some probiotics, cheap potato starch and other fermentable fibers from food will work just as well or better is immaterial to me. Only a fraction or people will do that. Most love the attention they get from their doctors and look upon pills as a panacea. They always call it “medication.” They love to require “medication.” So, oh well. Good, I suppose.

~ NM504 is also being studied in a placebo-controlled, double-blinded, proof of concept trial testing its utility in combination with metformin in type 2 diabetes patients with adverse gastrointestinal effects.

From the same DiabetesHealth article

In a recently-published case study, NM504 demonstrated the potential to mitigate the GI side effects associated with metformin.

The gut microbiome plays an important role in regulation of metabolic processes, including digestion, absorption, and synthesis of bioactive molecules that signal physiological host mechanisms. Changes in the human gut microbiome are associated with type 2 diabetes and insulin resistance. Water-soluble dietary fibres like inulin and beta-glucan are fermented in the colon, and beta-glucan increases viscosity. Blueberries improve insulin sensitivity through an antioxidant effect. A cobiotic, consisting of purified inulin, sugar-free blueberry pomace extract, and an oat preparation of purified beta-glucan was developed for twice a day (bid) consumption as a smoothie drink to repair the gastrointestinal dysbiosis in type 2 diabetes. A 30-year-old man presented with new onset type 2 diabetes and a fasting glucose (FBS) of 375 mg/dl. Metformin 500 mg bid was initiated and increased to 1 g bid after 1 week. During the first 9 days of metformin treatment, he developed diarrhoea, but his FBS only dropped to 325 mg/dl. The cobiotic bid was added on the 9th day of metformin treatment, and after 2 days, his FBS dropped to 175 mg/dl. After 8 weeks on metformin and the cobiotic, his blood sugar was 100 mg/dl and he lost 5.5 kg. His stools became soft and formed on the cobiotic, reverted to diarrhoea when off of it for 2 days, and returned to normal on resuming the cobiotic formulation. Metformin is a safe, effective and inexpensive generic medication favouring weight loss, recommended as initial treatment of type 2 diabetes by the American Diabetes Association. However, a 20% incidence of diarrhoea limits its tolerability. A safe food supplement that can increase the efficacy of metformin and its tolerability, as occurred in this case report, would have significant positive public health consequences. A controlled clinical trial of the cobiotic with metformin is planned.

Interesting times lie ahead.

MBT is developing microbiome modulators that alter microbial populations and their environment in the gastrointestinal tract to address serious health conditions. The company’s microbiome modulators are designed to act on multiple factors, augmenting the growth of targeted desirable bacterial strains and discouraging the growth of others. NM504 is formulated to promote microbiome shifts that positively affect metabolism and weight.

We’ll see. At minimum, it appears the focus in now on actual root causes of things.

Richard Nikoley

I'm Richard Nikoley. Free The Animal began in 2003 and as of 2021, contains 5,000 posts. I blog what I wish...from health, diet, and food to travel and lifestyle; to politics, social antagonism, expat-living location and time independent—while you sleep—income. I celebrate the audacity and hubris to live by your own exclusive authority and take your own chances. Read More

50 Comments

  1. bornagain on February 21, 2014 at 14:15

    The suspense of your upcoming soil test is killing me! Not since the TV series Breaking Bad have I experienced such excitement over the next instalment of a series.

  2. bornagain on February 21, 2014 at 14:23

    Regarding digestion of vegetables: prior to RS beetroot and corn would come out the same colour it went in. It was like shitting paint the colour was that bright. Not anymore! Corn completely, yes completely, dissappears and beetroot does nothing but add a slightly darker shade of brown.

  3. gabriella kadar on February 21, 2014 at 15:02

    I hear the sound of tectonic plates shifting.

  4. MycroftJones on February 21, 2014 at 15:40

    The question now is, why is the effect temporary? A few weeks ago someone linked to a study in Mali, where the starving children were given a different diet, and they were finally able to put on weight. When they put on weight, their gut bacteria changed to match the healthy children who ate the traditional Mali diet.
    When the gut bacteria were “normal”, they switched the children back to the Mali diet. The gut bacteria changed back to how it was before, and they went back into starvation, not being able to process food.

    Now in this news, the people taking the probiotic pill lose the benefits after two days of not taking it.

    So…. what is going on? What is it in the body that is killing the good bacteria? 2 days seems way too fast for the gut bacteria to die out completely, even if you aren’t supplementing with RS.

    Having the right bacteria and balance of bacteria isn’t enough.

    Once you add back in the bacteria that were killed by anti-biotics and other causes, there is still something else that is wiping out beneficial gut bacteria.

    I haven’t noticed any particular changes from RS (no downsides either, so its all good). I’m ready to start taking probiotics, if I can find good ones. Some fellas were advocating shit transfusions, but I’m not sure I’m that desperate yet. Besides, who does anyone know that is healthy enough you’d trust it? This is as dangerous as blood transfusions.

    This is definitely a rich field for study.

    • Allan Folz on February 21, 2014 at 17:38

      I’ve read about the loss of therapeutic effect following the suspension of probiotics before.

      Apparently the bacteria in the probiotic are unable to establish a permanent colony in the gut. Why it seems to work with fecal swaps while it doesn’t with probiotics in a capsule, I’ve not seen explained. I can imagine a few explanations, but they would just be guesses. I am curious what the real difference is, and I hope someone figures it out.



    • MycroftJones on February 21, 2014 at 18:05

      Be interesting to see if fecal transplants would permanently fix those kids in Mali, after the diet change only gave temporary benefits.

      I wasn’t aware that fecal transplants give long lasting benefits; perhaps it isn’t just the bacteria that is needed, but the “bacteria colony” including some of the matter that they reside on, sort of like with kefir. With kefir you can’t just isolate the bacteria and get new kefir; the whole colony, with the ropes and everything is needed.

      So if fecal transplants are what is needed, how do you find healthy donors? How do you identify someone who is healthy?



    • gabriella kadar on February 21, 2014 at 18:26

      Alan, nice to see your name pop up. Have you guys got the poop test kits yet?



    • CT on February 22, 2014 at 00:12

      I haven’t got any proof, but my theory would be that the bacteria need some time to settle down, buying a house, getting a car and stuff before they are permanent residents in the area.

      Just the other day I think Richard posted something about how the appendix stores bacteria to reboot the gut flora, if that’s the case maybe it takes a while before the new bacteria moves in to the appendix.



    • Todd on February 22, 2014 at 07:36

      Eating foods treated with antibiotics and anti-pesticides?

      If people are eating conventional meat and veggies, are we constantly attacking our gut flora?



    • Allan Folz on February 22, 2014 at 11:56

      Oops, sorry for the drive-by comment (ie. delayed response). Yep, got the kits and have sent in the “before” samples. We’re one week into the experiment at this point. Some time this weekend I was going to post a bit of an update over at the blog page with some of my early thoughts and experiences. Thanks for asking.



  5. VW on February 21, 2014 at 17:35

    Getting Dr. Ayers on the team is a great move, if that’s what’s happening here.

  6. Heisenbug on February 21, 2014 at 18:41

    “The missing bacteria will not be regained upon return to eating plants again.”

    I don’t see the support for that statement. In fact, the seasonal pattern of hunter-gatherer eating would directly contradict that. Hadza seem to do ok eating nothing but honey for a few months out of the year.

    This is similar to a contention from Dr. Ayers’s last post, stating that it might be necessary to consume some probiotics to make RS work. I don’t see support for that either — exogenously consumed LAB bacteria (and SBOs, for that matter) don’t really colonize and wouldn’t play a significant role in this.

    • gabriella kadar on February 22, 2014 at 07:48

      My understanding of the SBOs is to outcompete and use bacterial produced anti-biotic to eliminate pathogenic bacteria, especially from the small intestine. For example, subtilisin produced by B. subitilis is antibiotic against bacterial dysentery and probably others as well.

      The missing bacteria consequent from antibiotic use and poor eating habits will have to gradually repopulate via food sources which are ‘contaminated’ with the ones that are missing. Probably a slow process.



  7. Richard Nikoley on February 21, 2014 at 21:30

    “I don’t see the support for that statement.”

    That’s because you come from the context of Western Civ clean rooms, that we all live in, compared to bushmen. It may be that gut bacteria don’t really colonize as we think of it, building cities and suburbs, watching Jonny “E. coli” Carson and Craig “C. diff” Ferguson every night.

    These people are ingesting live and dead bacteria and spores all the time.

    That’s a difference you have to account for.

  8. Jew Lee Us C Czar on February 21, 2014 at 21:57

    “Use it or lose it.”

    Great advice. That is why I eat a diet that includes everything: meat, dairy, fruit, vegetables, grains, starches, and everything else in between. This was an idea that was floating around on the 180 Degree Health blog quite a few years ago.

    I’m like the borg. Assimilate everything and make it part of my being. Absorb what is useful and shit the rest out.

  9. TempestTcup on February 21, 2014 at 22:03

    I’ve been following this since the beginning and have experimented along, and my only question is: if I pay attention to my gut and butt flora and my husband doesn’t, will my flora automatically transfer? We share a lot of fluids 🙂

  10. Karen on February 22, 2014 at 00:23

    Richard, forgive me if this has been answered elsewhere = can you please list (or point me to one) the most beneficial strains of probiotic? I’m researching new sources in my neck of the woods and want to get the best bang for my buck.

    • Richard Nikoley on February 22, 2014 at 06:24

      Karen

      I’m using these

      – Prescript Assist
      – AOR Probiotic-3
      – Primal Defense Ultra

      One of each, twice per day. I’ll be posting about it next week.



    • Karen on February 22, 2014 at 09:02

      Ah. These ones aren’t available domestically. Could you tell me the names of the various strains they incorporate? Sorry! And thank you!



    • Richard Nikoley on February 22, 2014 at 11:23

      If you Google around for the product info I’m sure it’s not to hard to find. Prescript assist has like over 20 strains.



    • Marie on February 22, 2014 at 11:50

      Hello wondering what your thoughts are regarding this article.
      Thanks!

      http://fixyourgut.com/hso-probiotics-not-as-safe-as-they-are-believed-to-be/#comments



    • gabriella kadar on February 22, 2014 at 13:22

      Marie, I had been reading various reports as well. The Italian guy with leukemia who died because of taking B. subtilis.

      I watched Natasha Campbell Mcbride’s presentation and she acknowledges that people with severe problems must not take SBOs at regular doses. She recommends a capsule be opened and only a tiny amount taken and certainly not every day. I can’t remember now how infrequently (? once per week) but she says it can take a long time before SBOs can be taken at full dose. Then only for a certain period of time while needed.



    • Richard Nikoley on February 22, 2014 at 14:07

      Meh, the date is 2003, 11 years ago, for the principle reference. Natasha Trenev is a competitor, so there’s 2 strikes there.

      Perhaps I’ll drop dead. Until then, at least I can breath clearly for the first time since I can remember.

      Strike 3.



    • DuckDodgers on February 22, 2014 at 17:11

      Marie,

      Chris Kresser responded to those concerns here.

      Chris Kresser wrote:

      There is a lot of confusion about this topic. Jini Patel has raised concerns about soil-based organisms (SBOs) in this article, based on claims made by Natasha Trevnev, the founder of Natren (a company that sells lactic acid-based probiotics). Most of the objections raised in the article are either technically inaccurate or outdated by current research. It has become clear through DNA sequencing of the gut microbiota that the human gut has a makeup of bacteria similar to or already of SBO origin. From an evolutionary perspective, it’s likely that we were exposed to SBOs to a much larger degree than we are now, due to the industrialization of agriculture and food distribution, and changes in soil quality and diversity.

      The term “spore former” refers to microflora that can form spores that are biologically active, i.e. reproduce in the spore form, and are highly resistant to the environment and cause disease. Endospore formers, on the other hand, are biologically inactive and remain that way until environmental conditions allow resuming normal forms. Prescript Assist does have endospore formers, but they simply pass out of the system if they ever form in the gut of any mammal.

      The Relman-Stanford group studies have shown that SBOs are more numerous in the gut than lactic acid microflora, and that the microflora resident in the healthy mucosa of the gut differ considerably from what is present in fecal material (which tends to have higher numbers of lactobacilli and bifidobacteria).

      Finally, Prescript-Assist microflora are recognized Class 1 Etiological Agents, non-toxic, non-pathogenic, from independently maintained lines — this is well documented in both of the Clinical Therapeutics Articles. More than a decade of use as a supplement has revealed no adverse effects and/or side-effects [including reportedly patients with impaired immune systems], as well as the initial demonstrations with repeated consumptions of doses amounting to 500X that recommended for ordinarily daily use with no ill effect.

      Sounds like people in the dairy-based probiotics industry decided it would be good for business to spread false and unsubstantiated rumors about SBOs.



    • Marie on February 22, 2014 at 19:20

      Thanks to everyone for your input on this!



    • Eric Tran on February 23, 2014 at 22:16

      Ah, just saw this. Sorry for asking redundantly…



    • Grace/Dr.BG on February 24, 2014 at 02:56

      Thanks Duck 😉

      I believe anyone on chemotherapy (which breaks the gut and induces instant intestinal permeability) and anyone with low WBCs (white cell counts, aka super low immunity), many probiotics are contraindicated.

      A search of pubmed will produce a list of septicemia with any probiotics (LAB, bifido and otherwise) with severe immunocompromised states.

      Gab~ I love u and this article you brought up earlier. This explains FTA and the ‘failures’ no? This article was almost 20 years ago. I bet the results would be somewhat worse now, my suspicion…

      Br J Nutr. 1996 May;75(5):733-47.
      Digestion and physiological properties of resistant starch in the human large bowel.

      Cummings JH, Beatty ER, Kingman SM, Bingham SA, Englyst HN.
      Author information

      Dunn Clinical Nutrition Centre, Cambridge.
      Abstract

      The digestion of four sources of resistant starch (RS) has been studied in twelve healthy volunteers who ate controlled diets for 15 d periods. RS from potato, banana, wheat and maize (17-30 g/d) was compared with a starch-free diet, a diet containing wheat starch that was fully digested in the small intestine, and with 18.4 g NSP from brand/d. RS increased stool wet weight by 1.6 g/d per g RS fed for potato, 1.7 for banana, 2.5 for wheat and 2.7 for maize, but this was significantly less than bran NSP at 4.9 g/g. RS was extensively digested in twenty-seven of thirty-four diet periods but five subjects were unable to break down one or two of the RS sources. Faecal N and energy excretion were increased. RS decreased NSP breakdown and RS2 (resistant starch granules) tended to prolong transit time. All forms of RS increased faecal total short-chain fatty acid excretion. RS2 (from potato and banana) gave greater proportions of acetate in faeces, and RS3 (retrograded starch from wheat and maize) more propionate. We have concluded that RS2 and RS3 are broken down in the human gut, probably in the colon although in 26% of cases this breakdown was impaired.RS exerts mild laxative properties, predominantly through stimulation of biomass excretion but also through some sparing of NSP breakdown.



    • JB on April 12, 2014 at 22:55

      Natasha Trenev is the owner of Natren, a producer of lactic acid based probiotics – agenda perhaps? Her recommendations and fear mongering against SBO’s has not a single relevant citation behind it. And so miss Jini Patel is basing her entire recommendation on the scientifically unsubstantiated word of Natasha Trenev? Pfff…



  11. Heisenbug on February 22, 2014 at 06:32

    Whether it’s a bushman or David Letterman, your gut will be largely comprised of bacteroides, prevotella, or clostridia, with a few other leading characters. These are not in fermented foods, or probiotic pills, or the potato chip on the ground that falls within the 5 second rule. They are in you. The amount and proportions will depend on diet.

    That’s why FMT is probably the only thing that holds any real promise (if something other than diet is really called for). But even then, the jury’s out on everything but C. diff infections, because all you’re really doing is eradicating a pathogen by flooding it with a hostile environment for a while. Doesn’t really require anything to stick long term.

  12. LeonRover on February 22, 2014 at 07:07

    My mind boggleth ath these blog comments.

    Linking Heisenbug’s lack of certainty with TempestuousCup’s question on transfers of butt flora with her husband produces the advice that FMT (Friendly Microbiotic Transfer) heavenly peaks can be achieved between consenting adults while listening to

    http://www.youtube.com/watch?v=GeisCvjwBMo

    Sláinte

    Vagabond

  13. LeonRover on February 22, 2014 at 07:14

    PS

    And Les Francaises & Francophiles do it “Chic to Chic”.

    While Desert Lovers do it ” ….k to ….k”.

  14. Heisenbug on February 22, 2014 at 08:21

    Oh also, Richard, to be clear, I do see your point on the continuous exposure of the environmental bugs, and how “colonization” wouldn’t really apply. I agree. I just think they are involved in (very important) processes that are outside of the commensal/fermentation/SCFA process. That’s where I think Ayers gets things mixed up.

  15. Keoni Galt on February 22, 2014 at 09:28

    Use it or lose it. Art goes on to talk a lot about the need for probiotics, and not all that stuff in yogurt, kefir, or any other lacto-strains.

    I’m at a loss here Richard….I’ve been reading Art’s blog almost as long as I’ve been reading yours. I found this latest convergence of RS with his Cooling Inflammation pretty neat, but I am puzzled to see you omit Art’s recommendation for adding missing gut bacteria – eating fermented vegetables.

    ” So, here comes the part that was missing from Nikolay’s Paleo plus RS. He left out the missing gut flora. RS is a panacea for those with some gut bacteria that can digest RS, but for those with profoundly crippled gut flora, e.g. some of those with autoimmune symptoms, RS is just inert fiber, not flora food.

    New bacteria must be eaten, and I think that the cure, short of the real deal fecal transplant, is still available in the original, paleo form of naturally fermented, live foods. The answer (and please forgive the fervor, because I think health can be this simple) is Fermented Vegetables”

    I have eaten a whole bag of BRM potato starch, 4 tbsps a day with my organic yogurt last month, thanks to your blogging on the topic. I noticed almost zero difference in health, feeling, digestion etc….the only noticeable thing was perhaps a little bit more vivid dreams and that’s about it.

    But this entire experience helped me realize that I’ve been consistently eating a good amount of fermented vegetables (kim chee, sauerkraut, poi) and RS in the form of cold rice for a number of years now, so great. I also quit being a germophobe several years ago, and haven’t taken any antibiotics in well over 5 years.

    Anyhow, keep up on preaching the good word on RS. I used to always refer people that asked me about diet to Mark’s place…but lately I’ve been telling folks about RS and FTA almost as much as Mark’s Primal paradigm.

    • Richard Nikoley on February 22, 2014 at 12:00

      Keoni, not an oversight to not address that, because I plan to address it when I post about probiotics specifically next week.

      Now, I’m off to go get some fresh sauerkraut, pickles and kimchi. Oh, and some natto.



  16. Charles on February 22, 2014 at 10:20

    I started taking those three probiotics a couple of months ago, and there was a definite period of adjustment after just taking Prescript Assist for the first four+ months with PS.

    Also, I just made a “smoothie” with water, 15 g. BCAAs, 15 g. of a Glutamine-Alanine di-peptide, a couple of tablespoons of potato starch, some matcha powder, a little stevia and a hand full of blueberries. I couldn’t eat anything right now if you set my favorite food reward junk food (pulled-pork nachos!) in front of me and held a gun to my head. (I put “smoothie” in quotes because it’s not the most delicious thing you ever ate, though it’s not too bad.) The Glutamine-Alanine dipeptide is to help repair leaky gut, if anyone is interested.

  17. Eric Tran on February 22, 2014 at 15:17

    Hi Richard,

    Just started going through your blog. I have gone through about 10 of your RS posts and really like how you pile on the research on people. I would like to do that type of research myself but it’s just nice and convenient when there is a guy like you who can do that for us.

    Anyways, I am really interested in hearing about the probiotic supplements that you use because I realized that I have been going through a stage of daytime fatigue that wasn’t always there. I attribute this to a 1-month stint on Accutane (an acne anti-biotic) that I took in high school. I got a yeast infection that appeared on my face within 2 weeks of using it and stopped at the end of the 4th. The yeast infection went away and my skin did get clearer but I feel tired all the time now. Been reading various health blogs for a while to figure out what to do and I think that this RS info is going to help me. I am particularly interested in hearing more about what probiotics you used and mentioned in this post and will keep my eyes on the blog to know which probiotic supplements you recommend!

  18. Eric Tran on February 22, 2014 at 15:22

    Also, I am willing to take poop pills (honestly) if that’s what you recommend. As long as they’re in capsule form I mean.

  19. jo on February 23, 2014 at 07:01

    It would be really interesting to figure out what ingestable would assist the development of NM504 in the gut. Why wait for the approvals, the development, the marketing, the distrubtion? There must be a DIY for this one as well!

  20. jo on February 23, 2014 at 08:08

    Jeez….so NM504 is just a mix of “NM504 – a proprietary combination of purified inulin, beta-glucan and blueberry pomace extract”…I thought there would be some special kind of bacterial strain in there. F*&^$

  21. No guts no glory on February 23, 2014 at 11:41

    I thought of this site during a workshop with Sandor Katz on the weekend where he suggested that we can make sauerkraut by building alternate layers of cabbage and cooled mashed potato. An FTA complete food!

    • Richard Nikoley on February 23, 2014 at 15:43

      My Oma always served boiled potatoes with her sauerkraut and spareribs.

      All the critters are dead, but the elements are there.



  22. Grace/Dr.BG on February 24, 2014 at 03:05

    Richard~

    AWESOME POST! I appreciate you having me on board so I can keep kicking ur cute ass. 😉

    Thank you for posting on MBT NM504. O M G Hey this product sounds oddly familiar like the 7-steps (g banana/RS + SBO probiotics + Amazing Grass high ORAC green powder) for a high GI IQ and ultimate gut healing!!

    Maybe they will even REVERSE T2D if probiotics were added????!

    “A cobiotic, consisting of purified inulin, sugar-free blueberry pomace extract, and an oat preparation of purified beta-glucan was developed for twice a day (bid) consumption as a smoothie drink to repair the gastrointestinal dysbiosis in type 2 diabetes.”

    • Richard Nikoley on February 24, 2014 at 07:53

      Grace

      Which Amazing grass product? Amazon sells a bunch of different ones.



    • Grace/Dr.BG on February 24, 2014 at 13:30

      15,000 ORAC value!

      http://www.iherb.com/Amazing-Grass-Green-SuperFood-Antioxidant-Berry-Drink-Powder-7-4-oz-210-g/35730

      Have you heard of WAPF and Pottenger? Raw foods are what our ancestors evolved on, no? We need their outsourced enzymes and nutrients that cooking can destroy. This formula though pricey also has some additional fiber and detoxing plant extracts that makes the combo BIONIC FIBER: g banana flour + RS + NSP/flavonoids.

      Personally I don’t like the cacao products — when I was ill something in it didn’t agree and I think it’s because it’s a raw legume (phytates? lectins?)



    • DuckDodgers on February 24, 2014 at 21:31

      It’s worth noting that some of these “green” powders have some quality control issues.

      https://www.consumerlab.com/results/print.asp?reviewid=greens

      For instance, the “Paradise energy greens” had excessive lead contamination at one point.

      http://oag.ca.gov/system/files/prop65/notices/2012-00308.pdf

      But, I believe the “Amazing Grass” brand passed the quality control tests from what I’ve come across, so it looks like a very good brand.



  23. Janet on February 26, 2014 at 13:41

    Been on PS up to 4 TBL about a month. Smaller amounts for about 2 weeks before. I am going to have to take a break as my eczema is nasty, painful and huge on my hand and on my leg actually wakes me up at night. It has only flared up this way since the PS intake. Never had eczema until 1 yr. into LC Paleo. This is the only thing eating differently, other than increasing my carbs to about a 1/2 cup of parboiled rice, sweet potatoes and some white potatoes. I have eaten these things fine on a LC transitioning Paleo in the last year. The good benefits are not outweighing the discomfort and ugliness of the eczema. I will see if things calm down after stopping and go from there. I am not on probiotics as of yet–kind of wanted to read Richard’s post first and these things are costly. Sorry, but $$ is a factor. I got bills! If the probiotics will help this situation, give me a shout and I will get them ordered because I would really like to see where this goes on RS with me.

    • gabriella kadar on February 26, 2014 at 14:35

      Heisenbug, check out his entry about the eczema he gets on his hands and the kimchi that seems to clear it up. Fermented vegetables have a lot of lactobacillus, so I guess that could be a start.



    • Janet on February 27, 2014 at 06:04

      Thanks. I will check this out and perhaps I can just get started with the lactobacillus, which I notice is in abundance in the local drug stores. His case sounds just like mine. There is sooooooo much out there, just in the Paleo world. I get confused. High histamine, FODMAP, creams–in some ways the internet can produce crazeee.



    • Janet on February 27, 2014 at 06:06

      I do make my own kombucha, but stopped a couple of months ago. I need to check what kind of probiotics are in that.



  24. Adrienne on March 5, 2014 at 10:55

    Does anyone have thoughts on why Korea appears to have such high rates of colorectal cancer despite consumption of large amounts of fermented vegetable fibers? I realize that smoking is a risk factor, but other countries are heavy smokers and do not appear to have the high risks for colorectal cancer that Korea does. I was looking at the info here:
    The link mentions that height is also a risk factor but then says calcium is likely protective yet Norway, Denmark and Netherlands (high dairy consumers) didn’t seem protected at all. I’m thinking that the stats may be generally useless because of all the confounding factors but the fact that Korea ranked so high seems odd if fermented veggies are in fact protective.

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