People are really getting good at refinements. Including myself. I now ingest probiotics (when I do, which is occasional, high dose) first thing AM with water, and wait hours before eating anything. The reason is simple. Your aim is to get them to the colon to establish as floral community members. You don’t want them being held up by food in transit, nor sidetracked by meals en route. So, one of my favorite mega-dose probiotics that you only take from time-to-time for six day, is Elixa Probiotic. Here’s a back-&-forth between Elixa’s creator, and Wilber, a commenter who’s a fiber menace to society.