You folks really need to try harder.
I do like Bill Davis and have had some nice exchanges with him going way back and most importantly, he was very friendly to the revolutionary work Tim Steele and I did here on Resistant Starch. I got notice of a post on a new study a couple of days ago that strikes me as a bit bright eyed.
Here’s the study. In fairness, it’s not yet published and so might be different in the final.
Wheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity
BACKGROUND/OBJECTIVES. The association between gluten and body weight is inconsistent. Previously, we showed that a gluten-free diet reduces weight gain without changing food intake in mice fed high-fat diets. In the present study, we investigated the effects of gluten intake on fat metabolism, thermogenesis and energy expenditure in mice fed a standard or high-fat diet.
METHODS. Mice were fed four different experimental diets during eight weeks: a control-standard diet (CD), a CD added with 4.5% of wheat gluten (CD-G), a high-fat diet (HFD) and a HFD added with 4.5% of wheat gluten (HFD-G). After the eight weeks, the mice received 99mTc-radiolabeled gluten orally to study gluten absorption and biodistribution or they underwent indirect calorimetry. After euthanasia, subcutaneous (SAT) and brown (BAT) adipose tissues were collected to assess thermogenesis-related protein expression. Lipid metabolism was studied in adipocyte cultures from the four groups.
RESULTS. Despite having had the same energy intake, CD-G and HFD-G mice exhibited increased body weight and fat deposits compared to their respective controls. 99mTc-GLU or its peptides were detected in the blood, liver and visceral adipose tissue (VAT), suggesting that gluten can even reach extra-intestinal organs. Uncoupling protein 1 (UCP1) expression was reduced in the BAT of HFD-G and in the SAT of CD-G and HFD-G mice. Indirect calorimetry showed lower oxygen volume consumption in CD-G and HFD-G groups compared with their controls. In HFD mice, daily energy expenditure was reduced with gluten intake. Gluten also reduced adiponectin, peroxisome proliferator-activated receptor (PPAR) α and PPARγ and hormone-sensitive lipase in cultures of isolated adipocytes from HFD mice, while in the CD-G group, gluten intake increased IL-6 expression and tended to increase that of TNF.CONCLUSIONSWheat gluten promotes weight gain in animals on both HFD and CD, partly by reducing the thermogenic capacity of adipose tissues.
International Journal of Obesity accepted article preview online, 07 October 2015. doi:10.1038/ijo.2015.204.
OK, let’s take a look.